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KMID : 0359720090270020142
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Journal of the Korean Neurological Association
2009 Volume.27 No. 2 p.142 ~ p.146
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The Effect of Androsterone as the Metabolite of Testosterone to Seizure Suppression
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Kim Won-Joo
Lee Byung-In
Cho Kyoung-Joo
Lee Soo-Yeon
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Abstract
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Background: Androsterone is one of the major metabolites from testosterone whose clinical importance remains unclear. This study evaluated the effects of androsterone on seizure susceptibility in mouse models of epilepsy.
Methods: The efficacy of androsterone (10~200 mg/kg, i.p.) against seizures induced by various GABA receptor antagonists and glutamate receptor agonists was evaluated.
Results: Androsterone protected mice against seizures induced by PTZ (pentylenetetrazol), PCX (picrotoxin), and DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in a dose-dependent manner. Androsterone did not protect against seizures induced by kainic acid, NMDA (N-methyl-D-aspartic acid), or 4-AP (4-aminopyridine) in mice.
Conclusions: These results suggest that androsterone exhibits anticonvulsant activity that occurs largely via nongenomic mechanisms. Testosterone-derived androsterone might be an endogenous protective neuroactive steroid in the brain.
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KEYWORD
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Androsterone, GABA, Seizure, Neuroactive steroid
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